Abstract
As part of our continuing work in the area of influenza neuraminidase inhibitors, a series of C3-aza inhibitors possessing a cyclic amine side chain was synthesized and evaluated for influenza neuraminidase inhibitory activity. Analogues possessing a six-, seven- and eight-membered ring, 4c-e, respectively, at the C3 position exhibited excellent influenza B neuraminidase inhibition.
MeSH terms
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Amines / chemistry
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Antiviral Agents / chemical synthesis
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Antiviral Agents / chemistry*
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Antiviral Agents / pharmacology
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Crystallography, X-Ray
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / chemistry*
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Enzyme Inhibitors / pharmacology
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Humans
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Influenza A virus / drug effects*
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Influenza A virus / enzymology
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Influenza B virus / drug effects*
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Influenza B virus / enzymology
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Neuraminidase / antagonists & inhibitors*
Substances
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Amines
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Antiviral Agents
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Enzyme Inhibitors
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Neuraminidase